Metal compounds in cancer therapy



Publisher: Chapman & Hall in London, New York

Written in English
Cover of: Metal compounds in cancer therapy |
Published: Pages: 256 Downloads: 272
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Subjects:

  • Organometallic compounds -- Therapeutic use.,
  • Cancer -- Chemotherapy.,
  • Metals -- therapeutic use.,
  • Neoplasms -- drug therapy.

Edition Notes

Includes bibliographical references and index.

Statementedited by Simon P. Fricker.
SeriesMetals in health and disease series -- 1.
ContributionsFricker, Simon P.
The Physical Object
Paginationxiv, 256 p. :
Number of Pages256
ID Numbers
Open LibraryOL18074073M
ISBN 100412542803
LC Control Number94072007

There is no doubt about the success of precious metals in the clinic, with, for example, platinum compounds being widely used in the treatment of cancer, silver compounds being useful antimicrobial agents and gold compounds used routinely in the treatment of rheumatoid arthritis. The medicinal properties of the other platinum group metals are now being recognised and of these a ruthenium. Ruthenium anti-cancer drugs are coordination complexes of ruthenium complexes that have anticancer properties. They promise to provide alternatives to platinum-based drugs for anticancer therapy. No ruthenium anti-cancer drug has been commercialized.. Since , when Cisplatin entered clinical trials, there has been continuing interest in alternative metal-based drugs. The leading ruthenium. Metals in medicine are used in organic systems for diagnostic and treatment purposes. Inorganic elements are also essential for organic life as cofactors in enzymes called metals are scarce or high quantities, equilibrium is set out of balance and must be returned to its natural state via interventional and natural methods.   The compounds were also effective against ovarian cancer cells which are resistant to the drug Cisplatin, the most successful transition metal drug, which contains the metal platinum.

  Led by Patrick Harran, UCLA’s Donald J. and Jane M. Cram Professor of Organic Chemistry, researchers produced a synthetic form of diazonamide that, in rodents, appears to be effective in fighting breast cancer, colon cancer and leukemia. The compound the scientists synthesized, DZ, is more potent and lasts longer in the bloodstream than.   Nanoparticles can surmount some essential problems of conventional small molecules or biomacromolecules (e.g., DNA, RNA, and protein) used in some diseases by allowing targeted delivery and overcome through biological barriers. Recently, silver nanoparticles have been harnessed as delivery vehicles for therapeutic agents, including antisense oligonucleotides, and other small molecules. A team of chemists from RUDN University synthesized new organosilicon compounds containing terbium and europium ions. These complexes have an unusual cage .

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These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that metal compounds have potential for activity not only as cytotoxic antitumour agents, but also in areas such as adjuvant therapy, diagnosis and immunotherapy.

The aim of this book is to review and describe the major. Ruthenium Compound in Cancer Therapy, G. Sava. Rhodium, Iridium and Palladium Compounds as Experimental Anticancer Drugs, G. Buckley. Organometallic Titanium, Vanadium, Niobium, Molybdenum and Rhenium Complexes - Early Transition Metal Anti-Tumour Drugs, P.

Kopf-Maier and H. Kopf. Anti-tumour Activity of Tin Compounds, A.J. Crowe. Metal compounds in cancer therapy book "Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications", edited by Andrea Bonetti, Steve B.

Howell, Roberto Leone, and Franco Muggia, provides succinct summaries of the major new developments in field of platinum drug therapy drawn from presentations made at the 10 th International. Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy PDF Free Download E-BOOK DESCRIPTION Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in and approved by the FDA for marketing in metal-based compounds used in the treatment of cancer.

6 This forms the foundation for the modern era of the metal- based anticancer drug. 5 Despite the wide use of the metal. The use of X-ray absorption and synchrotron based micro-X-ray fluorescence spectroscopy to investigate anti-cancer metal compounds in vivo and in vitro Metallomics, Vol.

5, No. 6 Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K Cell Lines. Free Online Library: Platinum and other heavy metal compounds in cancer chemotherapy; molecular mechanisms and clinical applications.(Brief article, Book review) by "SciTech Book News"; Publishing industry Library and information science Science and technology, general Books Book reviews.

There has been increased concern surrounding exposure to heavy metals due to the evolving understanding of their role in the development of cancer. This review highlights research related to the impact that heavy metals aluminum, arsenic, beryllium, cadmium, lead, mercury, nickel and radium have on human health.

Research was collected through PubMed, and it was compiled to assess the. Novel metals and metal complexes as platforms for cancer therapy. Frezza M(1), Hindo S, Chen D, Davenport A, Schmitt S, Tomco D, Dou QP. Author information: (1)Barbara Ann Karmanos Cancer Institute, Department of Oncology and Pathology, School of Medicine, Wayne State University, Detroit, MichiganUSA.

metal-based compounds used in the treatment of cancer.6 This forms the foundation for the modern era of the metal-based anticancer drug.5 Despite the wide use of the metal-based compounds, the lack of clear distinction between the therapeutic and toxic doses was a major challenge.

This was so because practitioners of ancient time lack adequate. The discovery of the anti-tumour activity of cisplatin in and its subsequent introduction into clinical trials in was the catalyst for a major research effort into the potential of metal compounds in cancer therapy.

This book draws together information on all metals involved in cancer therapy, including those used in radioisotopes. The idea for convening a Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy was born in an assembly of researchers from the Vermont Regional Cancer Center and the Norris Cotton Cancer Center who shared a common interest in metal complexes.

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients. Metal-based Anticancer Agents covers the interdisciplinary world of inorganic drug discovery and development by introducing the most prominent compound classes based on different transition metals, discussing emerging.

Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony.

Book • Browse book content in cancer research and therapy. Using drug delivery systems based on liposomes, magnetic nanoparticles, noble metal nanoparticles, polymeric nanoparticles, upconversion nanoparticles, quantum dots, or carbon nanomaterials gives scientists a new hope of finding solutions for curing cancer.

Nanostructures. "Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications", edited by Andrea Bonetti, Steve B.

Howell, Roberto Leone, and Franco Muggia, provides succinct summaries of the major new developments in field of platinum drug therapy drawn from presentations made at the 10 th International Manufacturer: Humana.

One example is photochemotherapy, or more specifically photodynamic therapy (PDT), which was an emerging concept inand where now McFarland and co-workers describe a compound that is in clinical trials. This project arose from a tumor-centered approach, as part of a complete PDT package that included a tailor-made compound together with.

Title:Organometallic Compounds in Cancer Therapy: Past Lessons and Future Directions VOLUME: 14 ISSUE: 9 Author(s):Pedro Martins, Mara Marques, Lidia Coito, Armando J.L.

Pombeiro, Pedro Viana Baptista and Alexandra R. Fernandes Affiliation:Departamento de Ciencias da Vida, Faculdade de Ciencias e Tecnologia da Universidade Nova de Lisboa, Campus de Caparica, Caparica.

Metal complexes in cancer therapy – an update from drug design perspective Umar Ndagi, Ndumiso Mhlongo, Mahmoud E Soliman Molecular Modelling and Drug Design Research Group, School of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa Abstract: In the past, metal-based compounds were widely used in the treatment of disease conditions, but the lack of clear.

Keywords: Cancer therapy, clinical trials, M-arenes, M-carbenes, M-carbonyls, metallocenes, nanovectorisation, organometallics compounds. INTRODUCTION Organometallic compounds are a type of coordination complexes containing at least one direct, covalent metal-carbon (M- C) bond [l].

Compounds containing metal to hydrogen bonds as. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. 2 Edited by H. Pinedo and J. Schornagel. Plenum Press, New York. x +. for the treatment of genitourinary and head and neck tumors and ofrheumatoid arthritis, respectively.

In addition, compounds of radioactive metal ions such as 99mTc and complexes of paramagnetic metals such as Gd(III) are now in wide­ spread use as imaging agents for. Since the discovery of cisplatin, a wide variety of metal complexes have been designed for the treatment of cancer and other diseases as well as for diagnostic purposes.

In this chapter, we review the binding events inorganic compounds undergo from administration to the biological target with a special emphasis on the strengths and weaknesses. Working from basic chemical principles, Metals in Medicine presents a complete and methodical approach to the topic.

Introductory chapters discuss important bonding concepts applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and.

The mechanism of action of metal-based chemotherapy drugs (the most widely used for treating common cancers like testicular or ovarian cancer) was the focus of. When I got my cancer diagnosis a couple of years ago, this book came highly recommended. I was disgusted with what I found.

In order to offer theories that validate or invalidate hundreds to thousands of years of reputation of certain herbs to combat cancer, 'researchers' are giving millions of innocent animals horrible cancers, to see how these herbs and compounds affect their health.4/5(2).

There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension.

for the wholefield. A listof clinicallyused chelating agents may be found inmost pharmacopoeia,15 while new chelating agents continue to be sought,16 The use of chelating agents in the treatment of Wilson’s disease is a good example of how medical problems due to free metal ion (CuII) toxicity may be ameliorated by chelating agents The extensive work on matrix metalloprotei.

Metal‐based drugs play a major role in the treatment and diagnosis of a wide variety of diseases. This chapter highlights some of the major developments that involve kinase and phosphatase inhibitors with the metal playing a crucial role in the inhibitory activity and in the modes of action for the treatment of diseases such as cancer and diabetes.

The final and classic book on metabolic therapy by the late, famed Dr. William Kelley (i.e. the Bible on the Kelley Metaboliic Therapy).

Alive and Well – One Doctor's Experience With Nutrition in the Treatment of Cancer Patients, by Philip E. Binzel, Jr., M.D. One of the two classic books on laetrile/Vitamin B.

There is increasing interest in the use of metal-containing compounds in medicine. This review describes several therapeutic applications, such as the use of platinum complexes in cancer chemotherapy, gold compounds in the treatment of arthritis, gallium in hypercalcemia, bismuth in anti-ulcer medication, and sodium nitroprusside in hypertension.Transition metal compounds as cancer radiosensitizers For reproduction of material from all other RSC journals and books: targeted radionuclide therapy (TRT) alongside radiosensitizing small molecules is a highly successful strategy for the treatment of cancer.

The major clinical impact of the radiosensitizing platinum(ii) dru.Natural Compounds in Cancer Therapy is a classic reference work for patients and medical professionals interested in use of nontoxic botanical compounds in the treatment of cancer.

It offers a snapshot of the field circaand its insights are still pertinent today. Natural Compounds in Cancer Therapy is among the first books to discuss the.